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Retatrutide is not yet approved in the UK and remains in clinical trials UK regulatory approval could potentially come in late 2025 or 2026 Current alternatives like Mounjaro and Wegovy are available now through private prescription Most patients will need to access these medications privately due to NHS restrictions Costs for current medications range from approximately 150-300 per month Managing Expectations and Preparing for Treatment If you are considering retatrutide or similar medications for PCOS management, setting realistic expectations is crucial for treatment success

Although a fairly large proportion of patients have reported a number of side effects, particularly at the gastrointestinal level (nausea, vomiting, diarrhoea), these side effects tend to diminish over time and adherence to treatment remains high, with about 5% of patients discontinuing treatment due to side effects

doi: 10.1016/j.bone.2013.06.029 55 YamagishiS

Carnitine is a molecule found mainly in fatty tissues that helps oxidize fats and use them for energy

The authors would like to thank Cline Brunon and Esther Jarrossay from Science et Surface (www.science-et-surface.fr) for XPS and FTIR spectra

M., Alonso, A